[摘要]目的：比较两组用药方案治疗重度痤疮的临床疗效，以期对临床用药有所指导。方法：将88例门诊重度痤疮患者随机分成A、B组，A组：给予罗红霉素胶囊+氯霉素酊治疗；B组：给予盐酸米诺环素胶囊+复方硫磺软膏治疗，8周后观察疗效。结果：A、B组治疗的总有效率分别为81.8%、79.5%，两组间总有效率比较，差异无统计学意义（P>0.05）；两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：对有适应证的重度痤疮患者，A组或B组或A、B组里的辅药互换都是治疗的不错选择。
[关键词]重度痤疮；罗红霉素胶囊；氯霉素酊；复方硫磺软膏；米诺环素胶囊；疗效
Abstract： Objective To compare the curative effects of two groups of medication on severe acne in order to guide the clinical medication. Methods 88 patients with severe acne were randomly spanided into 2 groups.A group were used Roxithromycin Capsules and Chloramphenicol Tincture.B group were used Compound Sulfur Ointment and Minocycline Hydrochloride Capsules.Then observed the curative effect after 8 weeks. Results A group's total efficiency was 81.8%，and B was 79.5%（P>0.05）.There were no significant differences between two groups. The main adverse reactions incidence were no significant differences（P>0.05）. Conclusion The two groups of medication are good choices on severe acne.
Key words：severe acne；roxithromycin capsules；chloramphenicol tincture；compound sulfur ointment；minocycline hydrochloride capsules；curative effect
1 资料和方法
1.1 病例选择
1.1.1重度痤疮的诊断标准：符合Pillsbury分类法Ⅲ～Ⅳ度。即面部、颈背部、胸部、出现较多粉刺、炎性丘疹、结节等情况者[4]。
1.1.3 排除标准：①患者不能完成治疗方案；②患者个人信息不全，对治疗效果及安全性评价无法评估；③妊娠及哺乳期妇女。
1.1.4一般资料：治疗观察的88例均为笔者医院皮肤科门诊患者。其中男50例，女38例，随机分成A、B两组，每组各44例。两组患者年龄、性别及痤疮分级构成比差异均无统计学意义，具有可比性。
1.3 疗效判定标准[3]
